Native Proteins and Derivatives
Biolegend Purified anti-Neurofilament L
Purified anti-Neurofilament L (NF-L) [NFL3]; Isotype: Mouse IgG1, κ; Reactivity: Human, Mouse, Rat; Apps: WB, IHC-P; Size: 100 μg
Cayman Chemical pGlu4MyelIn BasIc ProteIn 25mg
An internal standard for the quantification of 6-ECDCA by GC- or LC-MS
Sigma Aldrich Fine Chemicals Biosciences Lipoprotein Lipase from Ps10MG
Lipoprotein Lipase (LPL) is majorly secreted by myocytes and adipocytes in humans and is crucial for triglyceride homeostatis. Mutations in the catalytic domain of LPL impairs its interaction with glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1). The N-terminal catalytic domain is essential for lipolysis. The C-terminal is crucial for binding lipoproteins. Altered LPL levels may play role in the pathogenesis of atherosclerosis coronary heart disease and chronic lymphocytic leukemia.
Cayman Chemical Nat-20 S-yn 10mg
A TLR3 TLR8 and TLR9 receptor agonist selectively induces NF-KB activation in HEK293 cells expressing recombinant human TLR3 TLR8 or TLR9 (EC50s 4.8 13.45 and 5.66 UM respectively) over HEK293 cells expressing recombinant human TLR2 TLR4 TLR5 or TLR7 (EC50s >100 UM for all) induces TNF-a IL-6 and IL-8 production in THP-1 cells from 5-40 UM inhibits the growth of HeLa cells (IC50 2.71 UM)
ILEX LIFE SCIENCES LLC HUMAN THROMBIN PROTEIN 1 MG
Ilex Life Sciences Thrombin Human, Purified Protein (Plasma), 1 mg. CAS REGISTRY NO.: 9002-04-4. BIOLOGICAL ACTIVITY: The specific activity was found to be 2435 NIH Units/mg (NOTE: may vary with each lot number, please refer to the datasheet enclosed with your product). FORMULATION: Sterile filtered liquid solution; contains 0.15M NaCl, 0.1M Tris, pH 7.4. APPLICATION: As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity. OTHER NAMES: Native Activated Factor IIa, Factor 2A, F2, PT, RPRGL2, THPH1, coagulation factor II, EC 3.4.21.5, UniProtKB# P00734.
ILEX LIFE SCIENCES LLC PORCINE THROMBIN PROTEIN 1 KU
Ilex Life Sciences Thrombin Porcine, Purified Protein (1000 U). DESCRIPTION: Thrombin Porcine, purified native enzyme, lyophilized. CAS REGISTRY NO.: 9002-04-4. FORMULATION: Sterile filtered white lyophilized (freeze-dried) powder. Lyophilized powder from glycine, calcium chloride pH 7.0 containing 0.9% NaCl. OTHER NAMES: Native thrombin protein, Porcine Activated Factor IIa, Factor 2A, F2, PT, RPRGL2, THPH1, coagulation factor II, EC 3.4.21.5, UniProtKB# P00735. APPLICATION: As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.
Cayman Chemical ClusterIn MoncLNalCLN 9 100uL
An inhibitor of cardiac myosin ATPase (IC50 1.26 UM for the bovine enzyme) reduces fractional shortening in isolated rat cardiac ventricular myocytes (IC50 7.9 UM) as well as in rats in a dose-dependent manner
Cayman Chemical PSelectIn GlycoproteIn LIgn
An imidazole displays excitation/emission maxima of 382/466 nm respectively when complexed with trichloroacetic acid
Cayman Chemical Sp2DeoxyadenosIn5O 1 2.1mg
An ETA receptor antagonist (Ki 13 nM in rat aortic vascular smooth muscle cells) inhibits ET-1-induced contractions in isolated rat aortic rings and mesenteric microvessels (pA2s 8.1 and 7.97 respectively) decreases systolic blood pressure in DOCA-salt hypertensive rats at 50 mg/kg decreases MAP and LVDP in normotensive pigs at 1 and 5 mg/kg reduces myocardial infarct size as a percentage of the area at risk in a porcine model of LAD coronary artery ligation-induced ischemia-reperfusion injury
Cayman Chemical 8ChloroadenosIn5trIphosp 2.7mg
An antimycobacterial agent active against M. tuberculosis and M. bovis (MICs 0.38 and 1.6 UM respectively)
Cayman Chemical Dansyl Amde 1g
An internal standard for the quantification of gemfibrozil by GC- or LC-MS
Cayman Chemical RpGunosIn5O 1thIotrIp 2.7mg
An aldose reductase inhibitor (IC50 28.9 pM) reduces infarct area in streptozotocin-induced diabetic mice expressing human aldose reductase in a model of cardiomyopathy induced by ischemia-reperfusion injury at 40 mg/kg
Cayman Chemical CalpaIn InhIbItr I 10mg
Reacts with thiols resulting in an increase in fluorescence intensity of up to 120-fold the response is selective for thiols occurs in aqueous media and results in a fluorophore with emission at 623 nm cell-permeable
Cayman Chemical CalpaIn InhIbItr XII 5mg
A MRN complex inhibitor inhibits DSB-induced H2AX phosphorylation (IC50 66 UM in X. laevis cell-free extracts) inhibits the exonuclease activity of Mre11 in a cell-free assay at 100 UM induces cell cycle arrest at the G2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner reduces tumor growth in an LA-N-5 mouse xenograft model when encapsulated in nanoparticles at 50 mg/kg
Cayman Chemical ChymostatIn 25mg
A naturally occurring diterpene that directly activates adenylyl cyclase to raise levels of cAMP in a wide variety of cell types binds to type 1 adenylyl cyclase membranes with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 M in an activation assay